Methyl 1-Boc-3-fluoropyrrolidine-3-carboxylate

Methyl 1-Boc-3-fluoropyrrolidine-3-carboxylate - Names and Identifiers

Name	1-tert-butyl 3-methyl 3-fluoropyrrolidine-1,3-dicarboxylate
Synonyms	Methyl 1-Boc-3-fluoropyrrolidine-3-carboxylate 1-tert-butyl 3-methyl 3-fluoropyrrolidine-1,3-dicarboxylate 1,3-Pyrrolidinedicarboxylic acid, 3-fluoro-, 1-(1,1-dimethylethyl) 3-methyl ester
CAS	942189-96-0

Methyl 1-Boc-3-fluoropyrrolidine-3-carboxylate - Physico-chemical Properties

Molecular Formula	C11H18FNO4
Molar Mass	247.27
Density	1.17±0.1 g/cm3(Predicted)
Boling Point	283.2±40.0 °C(Predicted)
pKa	-4.98±0.40(Predicted)
Storage Condition	2-8°C

Methyl 1-Boc-3-fluoropyrrolidine-3-carboxylate - Introduction

1-tert-butyl 3-methyl 3-fluoropyrrolidine-1,3-dicarboxylate is a pharmaceutical intermediate and an organic compound. The following is an introduction to its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless or light yellow oily liquid.
-Molecular formula: C10H15NO4F.
-Molecular weight: 239.23g/mol.
-Melting point:-35 ° C.
-Boiling point: 280 ° C (decomposition).
-Density: 1.222g/cm³.
-Solubility: Soluble in organic solvents such as ethanol and methanol, insoluble in water.

Use:
- 1-tert-butyl 3-methyl 3-fluoropyrrolidine-1,3-dicarboxylate is commonly used as an intermediate in the fields of medicine, pesticide and dye.
-It can be used for multiple important organic synthesis reactions to prepare various organic compounds.

Method:
The preparation method of-1-tert-butyl 3-methyl 3-fluoropyrrolidine-1,3-dicarboxylate is relatively complicated, and generally requires a multi-step reaction.
-The commonly used preparation method is to react 3-fluoropyrrolidine with tert-butyl Formic Anhydride to obtain an intermediate product, and then react with trimethylammonium bromide to obtain the final product.

Safety Information:
- 1-tert-butyl 3-methyl 3-fluoropyrrolidine-1,3-dicarboxylate is an organic compound and care should be taken to prevent contact with skin, eyes and inhalation.
-Wear protective gloves, goggles and protective masks during use or handling.
-Avoid contact with oxidants and strong acids during storage and handling.
-In the use of the process should strictly abide by the relevant safety procedures, such as well-ventilated laboratory conditions.
-For accidental exposure or inhalation, seek timely medical attention and bring the compound's safety data sheet.

Last Update：2024-04-09 02:00:52